AK Berg

Chemical Biology

Modulation of protein-protein interactions with small organic molecules

Protein-protein interactions form the basis of most biological processes, but represent very challenging targets for small organic molecules. The focus of our current research is to develop and apply innovative methods for the efficient design of small organic modulators of protein-protein interactions. These methods are applied for the synthesis and functional characterization of highly potent modulators of pre-selected protein-protein interactions. The developed small organic molecules are used as chemical probes to investigate biological questions and may serve as lead structures for drug development against proteins that were previously considered to be undruggable.

Research projects in our group combine synthetic organic chemistry with biochemistry, molecular biology and cell biology.


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letzte Änderung: 03.03.2020


Prof. Dr. Thorsten Berg
University of Leipzig
Institute of Organic Chemistry
Johannisallee 29
04103 Leipzig

Telefon: +49 341 9736-527
Telefax: +49 341 9736-599